By Mathew D. Morton NMD. A summary of ozone's
history and a brief overview of the various protocols of medical ozone
Ozone, a highly active form of oxygen, possesses unique properties which are
being defined and applied to biological systems a
s well as to clinical practice.
As a molecule containing a large excess of energy, Ozone manifests bactericidal, virucidal and fungicidal actions which makes it a treatment in other conditions.
Ozone, best known for its protective role in the earth's
ecological harmony, and for its interaction at ground level with industrial
has unique biological properties which have been
investigated for applications in various medical fields.
As early as the first World War, Ozone's bactericidal properties were used to
treat infected wounds, mustard gas burns and fistulas.
The first treatment attempts, however, were hampered by
technological difficulties. Medical Ozone generators have since been developed
They differ from industrial generators in their capacity
to deliver the purest Ozone-Oxygen mixtures in needed amounts.
A critical advance in medical ozone technology was the
development, in the early 60's of plastics which could adequately carry this
and permit proper administration to patients. Ozone is now
exponentially increasing in use by a diversity of therapeutic groups.
The oxygen atom exists in nature in several forms:
1) As a free atomic particle (0), it is highly reactive and unstable.
2) Oxygen (02), its most common and stable form, is colourless as a
3) Ozone (03) has a density one and a half times that of oxygen.
Ozone is a powerful oxidant. Of importance to biological systems is Ozone's
interaction with tissue, especially blood.
These dynamics are especially relevant for medical
applications because some of the most practiced methods in Ozone therapy
involve the mixing of a small volume of whole blood with a
pure ozone/oxygen mixture and subsequently returning it to the patient.
In this manner, it is calculated that the dose of Ozone
administered will perform its therapeutic functions without disrupting blood
The production of Ozone-Oxygen mixtures for human and
veterinary applications is subject to important technical consideration.
Clinical Ozone generators regulate the flow of medical
grade oxygen through high voltage tubes with outputs ranging from 4000V to
14,000V are capable of producing Ozone-Oxygen mixtures within concentration
ranges extending to five percent, predicated by three variables:
1) The voltage applied. 2) The oxygen flow rate. 3) The
electrode separation distance.
Since the half life of Ozone is 45 minutes at 68 degrees
Fahrenheit, in two hours losing its concentration to 16% of its initial value,
it must be freshly generated for immediate use at the
treatment site. The maximum dose generated is 5% Ozone to 95% oxygen.
Caution is needed not to mix ether and ozone, an
especially reactive mixture.
Also, no Ozone should be taken if the following conditions
are present: acute alcohol intoxication, recent heart attacks,
haemorrhage in any organ, pregnancy, hyperthyroidism,
blood clots and Ozone allergy.
METHODS OF ADMINISTRATION, DOSAGE AND CLINICAL APPLICATIONS EXTERNAL OZONE
Ozone was first administered by application to external body surfaces.
A.Wolff, in 1915, is credited for using local Ozone treatments
fistulas, decubitus ulcers and osteomyelitis.
Today, specially designed plastic, enables the body to be
comfortably encased in a space where a determined ratio of Oxygen to
Ozone is administered at a chosen flow rate.
Indication for external Ozone application include poorly
healing wounds, burns, staphylococcal infections, fungal and radiation lesions,
herpes simplex and zoster, and gangrene diabetic or
non-diabetic). Dosage is adjusted to the condition treated.
High Ozone concentrations are used for disinfection and
cleaning, while low concentrations promote healing.
Payr in 1935 and Augourg in 1936 first used Ozone-Oxygen mixtures in rectal
The list of indications has expanded to include many
Inflammatory diseases of the bowel, Ozone promotes healing and restores
the floral balance disturbed by harmful germs.
In a typical treatment, daily insufflations are applied
starting with 50 ml and increasing as tolerated in increments until 500 ml are
This technique is of use in the treatment of bowel
infections associated with AIDS.
Microsporidia, a tiny, rarely detected parasite may be responsible for
many cases of AIDS wasting illness this germ is susceptible to Ozone
MAJOR autohaemotherapy (AHT)
External Ozone applications produce local effects such as
disinfection, wound healing or local circulatory enhancement.
Ozone in the circulation as in the technique of major autohaemotherapy,
50 to 100 ml of blood is drawn from the patient,
mixed with a dose of Ozone-Oxygen, then returned via the
same intravenous catheter to the patient,
where the Ozonated blood is rapidly distributed to all
Blood infusions, Ozone exerts therapeutic actions locally;
virucidal activity, Oxygenation, increased red cell fluidity
and promotes increased beneficial systemic activity. Of
interest, patients report, after receiving this treatment,
experience feelings of well-being lasting for a few
minutes to several hours.
Although the above techniques of ozone administration represent the majority
of hospital or office based procedures, others deserve mention.
10 ml of venous blood is drawn from the patient, mixed
with Ozone-Oxygen, then injected intramuscularly.
Listed indications include asthma, acne, some allergic
conditions and some cases of arthritis.
OZONE IN WATER
Ozone is approximately ten times more soluble in water than oxygen. Mixed
into water, the half-life of Ozone is nine to ten hours at pH 7 and 68 degrees
It may be rinsed orally in conditions such as thrush and
periodontal disease, swallowed in cases of gastritis or stomach cancer, or
irrigated in chronic bladder inflammation.
OZONE OINTMENTS -
HERE for more
Ozonated olive oil provides long term, low dose exposure of Ozone to tissues,
and it may be used topically or consumed by drinking small amounts of used on
Ozonated water bubbled in warm baths provides stimulation
of local circulation and a disinfectant action to varicosities,
circulatory disorders and dermatological conditions
(eczema, ulcers, psoriasis, etc.)
METABOLIC AND PHYSIOLOGICAL EFFECTS OF OZONE
Pulmonary effects of Ozone in low doses include metabolic
activation of lung cells.
Below 0.30 ppm the probability of Ozone traversing
the respiratory epithelium and entering the systemic circulation is so low,
few studies have attempted to measure these effects. The technique of major autohemotherapy
and others that involve
the direct introduction of Ozone in the circulation, shows
that Ozone exposure increases metabolic activity of red blood cells.
According to other researchers, the direct intravascular
injection of pure Ozone/Oxygen mixtures results in the following response;
an activation of enzymes involved in oxygen radical
scavenging, releasing oxygen to the tissues.
BACTERICIDAL, FUNGICIDAL AND VIRUCIDAL ACTION
The inhibition and lethal effects of Ozone on disease
producing organisms have been observed since the latter part of the nineteenth
Ozone is a strong germicide needing only a few micrograms
per litre for measurable action.
Viruses differ in their speed of destruction by Ozone.
Ozone's bactericidal effects
centre on disruption of envelope integrity. There is interaction with proteins
The effect of Ozone on E. coli, is penetration of the cell
membrane. In clinical treatment Ozone is toxic to infecting organisms and not to
Ozone's fungicidal effects.
In one study, Candida cell growth inhibition with Ozone was greatly
dependent on phases of their growth,
budding cells exhibiting the most sensitivity to its
Viruses are parasites at the genetic level. Lipid-containing
viruses are sensitive to treatment with Ozone.
Viruses containing lipid coatings
include the Herpes viruses, a large family grouping the Simplex, Zoster,
Cytomegalovirus and Epsteinn-Barr viruses, mumps, measles, influenza, rabies and
the HIV virus.
In those clinical applications which make use of external
or body cavity application of Ozone, inactivation of micro-organisms,
bacteria, viruses or fungi, proceeds by a variety of
different methods. The treatment of burns, superficial infections,
ulcers and abscesses is approached by this method, which
is the absorption of Ozone through the skin and the mucous membranes.
Since very little free Ozone remains in the solution due
to its high reactivity, its products interact with circulation
as well as tissue-bound viruses, thus inactivating them.
Ozone blood treatment lessens clinical severity or duration. Thus,
therapeutic benefits have been noted in hepatitis, acute and chronic, and
In chronic viral infections-Cytomegalic, Epstein-Barr and
Retrovirus (AIDS) among others,
blood Ozonation administered during viral cycles or in
periods of clinical detection are, through the production of co-factors,
inhibitory to viral replication, modify immune function,
and are a tool in inducing viral suppression.
Ozone is an immunostimulant in low doses.