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THE USE OF OZONE IN VETERINARY HOSPITALS    
Ozone can be applied as a gas in a veterinary application in order to fulfil three purposes, as follows:

DEODORIZATION
Ozone gas is the most effective method of deodorising any area, with the advantage that it does not just mask, odours with chemicals, but actually oxidises the odour-causing bacteria, thereby getting rid of the source of the odour.

Because ozone reverts back into oxygen, it leaves behind no dangerous chemical residue that may harm your animals or staff.

Using ozone means that you no longer have to buy chemical sprays as deodorants. Not only is it more effective, but it is safer for staff and animals.

SANITATION
Because of its powerful oxidising qualities, ozone gas will kill all bacteria, viruses, fungus and spores in the air. This reduces the amount of disease, which can be transmitted by airborne viruses.

Ozone will sanitise the air, making it germ free, and so will aid recuperation of animals. It is also used medically to treat surface wounds on the skin.

Ozone is far more effective than conventional cleaning methods because as a gas, it goes into cracks, behind equipment, onto walls and ceiling, and all other areas which are inaccessible by conventional methods.

REMEDIAL
Ozone gas can be used at high concentrations to disinfect an area overnight, or clean a room or a vehicle, for example, which as been contaminated with a bad odour or infectious disease. For these purposes, ozone must be used at levels, which are toxic for animals and humans.

Therefore, the room or area to be disinfected should be closed and evacuated for a couple of hours or overnight, depending on the seriousness of the problem or level of contamination. After the treatment, simple ventilation of the room or area for several minutes with the doors and windows open will ensure that room is not only disinfected, but comfortable and safe for humans and animals to live in and work.

   
Veterinary Use of Intravenous Ozone and other Ozone Applications    
Part I - Viral (Rickettsial and Chlamydial) Diseases (VRCDs)

Ozone is very effective in acute and chronic viral diseases as a virucidal agent in reversing positive antibody tests and in improving the general health of the animals.

Ozone is the treatment of choice of Equine Infectious Enema (EIA, Swamp fever) and promptly reverses the clinical symptoms and a positive Coggins test.

Ozone is equally effective against Equine Ehrlichiosis and Potomac Horse Fever, caused by the rickettsial agents Ehrlichia equi and E. risticii respectively

Equine Encephalomyelitis (EE) including Eastern (EEE), Western (WEE),

Venezuelan (VEE) and other togaviral and flaviviral EE,

Equine Viral Arteritis,

African Horse Sickness (AHS),

Equine Herpesvirus I (EHV-1) infection

Equine Viral Rhinopneumonitis and Myeloencephalopathy

Equine Influenza and other VRCDs of horses and other animals including cattle, (e.g. chlamydial abortion from Chlamydia psittaci, et al.), cats, dogs, sheep, goats, domestic birds and various zoo animals.

Part II - Respiratory Diseases of Horses

Ozone is effective against respiratory viral infections (RVIs) (see part I) such as RVIs caused by EHV-1 (rhinopneumonitis), equine arteritis virus, rhonovirus, influenza.

Adenovirus pneumonia with combined immunodeficiency in Arabian foals.

Ozone is also effective against viral respiratory infections with secondary bacterial infection (see part III) that produces mucopurulent nasal discharge, exacerbates the cough, and may lead to lung abscessation, pneumonia or pleurisy. For ozone treatment of COPD (heaves), see part IV.

Ozone is the treatment of choice for Exercise-Induced Pulmonary Haemorrhage (EIPH, Epistaxis, "Bleeder"), especially in States and Countries that do not allow furosemide (LasixR). In most cases ozone reverses the bronchitis, neovascularization and fibrosis, and through a homeopathic mechanism, the other contributory factors of EIPH in "bleeders".

Part III - Bacterial Diseases

Ozone is very effective for acute and chronic bacterial diseases, including those that do not respond well to antibiotics such as:

Septicaemia in foals (e.g. from E. coli, Klebsiella spp

Actinobacillus spp.)

Leptospirosis (Leptospira interrogans)

Listeriosis (Listeria monocytogenes)

Contagious Equine Metritis (CEM from Taylorella equigenitalis)

Retained placenta with consecutive metritis, septicaemia and laminitis

Tularemia (Francisella tularensis)

Clostridial diseases e.g. Tetanus Enterotoxemia (Cl. perfringens infection) Malignant Oedema (Cl. septicum)

Botulism and Infectious Necrotic Hepatitis (Cl. novae)

Lyme Disease (Borrelia burgdorferi)

Actinobaccilosis (e.g. A. equuli in horses)

Anthrax

Melioidosis hematogenous septic polyarthritis with primary Brucellosis (Brucella melitensis, B. abortus, B. suis, B. canis, B. ovis, B. neotomae) and others, especially in valuable race horses and zoo animals.

Part IV - Fungal Diseases

Systemic Actinomycosis and Candidiasis

Chromomycosis

North American Blastomycosis, Histoplasmosis, Aspergillosis

A valuable adjunct in Chronic Obstructive Pulmonary Disease (COPD, heaves) of horses.

In the treatment of heaves, ozone relieves acute "asthmatic" attacks and the paroxysmal cough and effectively reverses the allergic component from inhalation of moulds, dust and other air pollution as well as the triggering respiratory infection.

Part V - Leukaemia's, Lymphomas and other Malignancies

Ozone is an effective adjunct to high-pH therapy and other treatment methods of the Life Science Universal (LSU) modalities for these conditions.

Ozone is a valuable adjunct for the treatment of Equine Sarcoids (generally in younger horses) and Squamous Cell Carcinoma (most frequently in older horses).

Ozone is particularly effective against any blood and malignant disease caused by viruses and bacteria such as Bovine Leukosis, Canine Malignant Lymphomas, Feline Lymphosarcoma, Feline Leukaemia and lymphoproliferative disorders in turkeys, chickens and zoo animals.

Part VI - Rectal and Other Typical Applications of Ozone

Rectal ozone insufflations are a powerful adjunct to the treatment of both infectious and non-infectious diseases of the digestive tract. Ozone is effective in reducing intestinal parasites (helminths), viruses and rickettsiae (see part I, e.g. Rotavirus and Ehrlichia in horses), bacteria (see Part III, e.g. enterotoxigenic E. coli, Salmonella spp., Rhodococcus (Corynebacterium equi in horses), protozoa and fungi (see Part IV, e.g. Eimeria spp. and Aspergillus fumigatus in horses) and algae (Prototheca spp.). Ozone is effective in diarrhoea and inflammatory bowel disease of horses.

Vaginal ozone insufflations are effective against vaginal Candidiasis (see Part IV, Vaginitis, Equine Coital Exanthema (EHV-3), Contagious Equine Metritis (see Part III).

Intramammary ozone application instead of antibiotics is effective for mastitis in large animals, e.g. mastitis in mares caused by Streptococcus zooepedemicus, S. equi, S. equisimilis, S. agalactiae and S. viridans.

Intra-articular ozone is effective for Septic Arthritis.

Topical ozone is effective for dermatomycosis, osteomyelitis and infected wounds, fistulae (e.g. fistulous withers and poll evil, i.e. inflammation of supraspinous and supra-atlantal bursae caused equine and bovine udder diseases.

Ozone is most valuable for Cattle Embryo Transfer Procedures.

Part VI - Dosage Recommendations - Please see below about dosages.

1) Intravenous Application of Ozone for the Indications Listed in Parts I-V Above:

To minimize potential inflammatory reactions and discomfort of the animals, inject IM orgotein prior to any IV O3 application. For best effectiveness and to minimize venous irritation use the largest available vein for IV O3 applications and/or different locations for each IV injection.

2) In almost all animals, IV O3 will produce a homeopathic-type "healing crises" (HHC). This HHC may temporarily increase symptoms of the present illness or produce symptoms of old unresolved conditions. An HHC is excellent proof of the effectiveness of IV O3.

a) Equine Infectious Anaemia (Swamp Fever):

Twelve IV applications on consecutive days of 0.5 milligrams of ozone per kilogram (0.5 mg O3/kg) then recheck Coggins test. If the Coggins test is still positive 4 weeks after the initial treatment series, repeat this series. In about 80% of the cases, the Coggins test becomes negative after one series.

b) Exercise-Induced Pulmonary Haemorrhage (EIPH, Epistaxis, "Bleeder"):

Twelve IV applications on consecutive days of 0.5 mg O3/kg combined with EDTA chelation at an EDTA dosage of 50 mg/kg.

c) Most Viral, Rickettsial, Chlamydial, Bacterial and Fungal Diseases:

Acute:

4 IV applications on consecutive days with 0.5 mg O3/kg. If symptoms have not subsided completely, the treatment may be continued up to 12 days.

1) Subacute:

6 to 8 applications on consecutive days of 0.5 mg 03/kg. Repeat after a treatment-free interval of 2 weeks if symptoms have not completely subsided.

Chronic:

{Such as Chronic Obstructive Pulmonary Disease (COPD, heaves)} 12 IV applications on consecutive days with 0.5 mg O3/kg. If symptoms persist after 4 weeks, repeat with 8 IV applications on consecutive days with 0.5 mg O3/kg. This 8-day regimen may be repeated every 6 weeks until symptoms have subsided completely or no further improvement is noted after O3 administration. All other precautions with COPD, such as strict avoidance of dusty and mouldy feed or air pollution, should obviously also be taken.

                    d) Leukaemias, Lymphomas, Sarcoids and Other Cancers:

8-12 IV applications on consecutive days with 0.5 mg O3/kg combined with the high-pH cancer treatment regimen pioneered by Life Science Universal.

    3. Rectal Application of Ozone:

Use approximately one litre ozone per 50 kilogram (1.0L O3/50 kg) at a concentration of 70 microgram per millilitre (70g/mL) and repeat procedure after 30 minutes. If the animal experiences significant discomfort, a smaller dosage may be required. Repeat up to 2x daily (b.i.d.) until the outcome is achieved.

Vaginal Application of Ozone:

Use approximately 1.0L O3/50kg at 70/mL concentration and repeat procedure after 20 minutes. If the animal experiences significant discomfort, a smaller dosage may be required. Repeat up to b.i.d. until the desired outcome is achieved.

Intramammary Application of Ozone:

Use 30, 60 up to 120mL or more, as tolerated at a concentration of 120g/mL and repeat every 10 minutes up to a total of six times. Repeat up to b.i.d. until the desired outcome is achieved.

Intra/Peri-Articular Application of Ozone:

Use 10 to 60 ml or more, depending on the joint, at a concentration of 70 to 120g/mL, and apply intra-articularly and also into the periarticular soft tissues, and set multiple periarticular intracutaneous wheals ("quaddels").

Topical Application of Ozone:

This may be done with a catheter or in some cases with a bag. For fistula or osteomyelitis treatments, use a concentration of 120g/mL and apply as large a volume as required 12 to 15 times with a catheter. Repeat up to b.i.d. until the desired result is achieved. For dermatomycoses and wound cleaning, use 70 to 120g/mL, and to enhance wound granulation, use 15 to 30g for a period of 20 to 40 minutes. Repeat up to b.i.d. until the desired result is achieved.

Cattle Embryo Transfer Procedure and Ozone:

Ozone ensures sterility for all procedures used in conjunction with cattle embryo transfer (CET) including artificial insemination, embryo recovery, handling, freezing and transfer. A step-by-step guide for the use of ozone for CET is available and is based on John L. Curtis' book, Cattle Embryo Transfer Procedure, Academic Press, 1991.

Important note

Recommendations in terms of dosages, concentrations, volumes and flow rates outlined in vi are extremely high. We suggest starting with a conservative approach (and increasing dosages if necessary later on).

A). IV application of Ozone:

0.05miligrams/kg => 50g/kg (per treatment) Concentration of ozone gas not exceeding 65g/mL [gamma]

B). Rectal Application of Ozone:

100ml ozone per 50 kilogram (0.1L O3/50 kg) concentration 30 - 35g/mL [gamma].

C). Vaginal Application of Ozone:

100ml ozone per 50 kilogram (0.1L O3/50 kg) concentration 30 - 35g/mL [gamma].

D). Intramammary Application of Ozone:

30, 60 up to 120mL or more, as tolerated concentration of 70g/mL

E). Intra/Peri-Articular Application of Ozone:

Use 10 to 60 ml or more, depending on the joint, at a concentration of 70 to 90g/mL, and apply intra-articularly and also into the periarticular soft tissues, and set multiple periarticular intracutaneous wheals ("quaddels").

F). Topical Application of Ozone:

This may be done with a catheter or in some cases with a bag. For fistula or osteomyelitis treatments, use a concentration of 90g/mL and apply as large a volume as required 12 to 15 times with a catheter. Repeat up to b.i.d. until the desired result is achieved. For dermatomycoses and wound cleaning, use 70 to 90g/mL, and to enhance wound granulation, use 15 to 30g for a period of 20 to 40 minutes. Repeat up to b.i.d. until the desired result is achieved.

G). Cattle Embryo Transfer Procedure and Ozone:

Ozone insures sterility for all procedures used in conjunction with cattle embryo transfer (CET) including artificial insemination, embryo recovery, handling, freezing and transfer. A step-by-step guide for the use of ozone for CET is available and is based on John L. Curtis' book, Cattle Embryo Transfer Procedure, Academic Press, 1991.

H). Ozonated Water (O3 X H2O)

Ozonated water has obvious multiple beneficial applications in veterinary medicine and surgery.

   
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Important
Ozone use covers such a broad spectrum of applications viz. agriculture, aquaculture, water and air purification, medical therapy, industrial process, sanitation, sterilization, etc.
Therefore be aware that-:
All Eco-Tec material is provided for information only and should not be taken as medical advice nor should any action or inaction be taken solely on its contents. Eco-Tec presents information, opinions and research believed to be correct and sound from expert authorities in many fields but their accuracy cannot be guaranteed. Please consult appropriate health professionals on any other matter relating to your health and wellbeing or consult a competent professional for answers to other specific needs.